Vol. 1 No. 1 (2023), Case Reports
Vol. 1 No. 1 (2023)

Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog

Case Reports
Published 2023-12-27
Yunho Jeong
Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea
https://orcid.org/0000-0001-9445-3606
Yoon-Hwan Kim
Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea
https://orcid.org/0000-0002-0727-9927
Jin-Ok Ahn
Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea
https://orcid.org/0000-0002-3300-6084
Jin-Young Chung
Department of Veterinary Internal Medicine and Institute of Veterinary Science, College of Veterinary Medicine, Kangwon National University, Chuncheon 24341, Korea
https://orcid.org/0000-0001-6729-9834
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Keywords

Case reports
immune thrombocytopenia
adverse drug reaction
anaphylactic shock
antibiotics

How to Cite

Jeong, Y., Kim, Y.-H., Ahn, J.-O., & Chung, J.-Y. (2023). Simultaneous hypersensitivity reactions to trimethoprim-sulfamethoxazole and amoxicillin-clavulanate in a dog. Editela Science Journal, 1(1), 199-203. https://esj.editela.com/index.php/esj/article/view/3
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Abstract

Antibiotics are known to be able to cause hypersensitivity reactions through various mechanisms. We present a case of drug-induced immune thrombocytopenia (DITP) and anaphylactic shock occurring simultaneously in a dog after the administration of two classes of antibiotics, namely trimethoprim-sulfamethoxazole (TMP-SMX) and amoxicillin-clavulanate (AMC). The patient recovered completely from DITP on discontinuation of TMP-SMX and the anaphylactic shock caused by AMC was treated with intensive care. DITP is a rare adverse drug reaction (ADR), and anaphylactic shock is a life-threatening ADR. This is the first case report of a dog manifesting two types of hypersensitivity reactions caused by two antibiotics.

 
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